Equine Sarcoids Triggered By Abnormal Tissue Changes During Wound Healing

by | 02.03.2016 | 12:01pm

Equine sarcoids, benign skin tumors that can be extremely frustrating to deal with, have plagued horse owners for years, but defied explanation.

A recent Italian study into equine sarcoids suggests that the tumors begin with abnormal tissue changes during the time the wound is healing.

Believed to be triggered by Bovine papillomavirus type-1 and/or bovine papillomavirus type-2, it is not clear how the virus causes the tumor. The Italian research team tested the theory that the virus lay latent in genetically predisposed equines and can be reactivated by immunosuppression or injury, which could turn into a sarcoid.

They examined 25 equine sarcoids and five normal skin samples microscopically. The study team also evaluated the immunohistochemical and molecular expression of a range of proteins. Their findings appeared to confirm that the basic mechanism for sarcoid growth could be abnormal tissue change during wound healing.

It is believed that understanding how sarcoids are triggered will open the door for the development of therapeutic approaches for treatment.

Read the full study here.

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