Antibiotic Injection Promising Additional Treatment For Uveitis

by | 01.29.2019 | 2:16pm

Equine recurrent uveitis (ERU) is an intermittent disease that is immune mediated. It causes inflammation in the eye on occasion, with periods of no inflammation or low-grade inflammation in between acute episodes.

The goal of ERU treatment is to reduce eye inflammation, preserve vision and reduce or eliminate pain. Current treatment involves immunosuppression and anti-inflammatories. Researchers have discovered that an injection of the antibiotic gentamicin directly into the affected eye can be added to the treatment protocol.

Drs. Britta Fischer, Richard McMullen, Sven Reese and Walter Brehm injected the vitreous humor (the jelly-like substance between lens and retina) of 86 horses with 4mg gentamicin. The response of 59 horses was taken from 30 days to 780 days.

The researchers, writing in BMC Veterinary Research, noted that 52 of the 59 horses were deemed that their uveitis was “controlled,” with no inflammation. Recurrent inflammation was recorded in five horses and persistent inflammation was diagnosed in two horses.

The study team notes that additional research is needed to see if gentamicin injections into the vitreous humor could control persistent and recurrent inflammation, but that the treatment shows promise.

Read more at HorseTalk.

Read the study here

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